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pile of spaghetti squash casserole on white plate.
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Chicken Spaghetti Squash Bake

This chicken spaghetti squash casserole is a riff on the classic chicken spaghetti. It's creamy and cheesy with a bit of spice from the diced tomatoes and chiles and sweetness from the spaghetti squash.
Course Chicken
Cuisine American
Keyword chicken spaghetti squash
Prep Time 30 minutes
Cook Time 1 hour 20 minutes
Total Time 1 hour 50 minutes
Servings 6 servings
Calories 553kcal

Ingredients

  • 1 whole spaghetti squash about 3 pounds
  • 1 1/4 cups heavy whipping cream
  • 2 ounces cream cheese
  • 2 tablespoons butter
  • 1/2 teaspoon ground mustard
  • 1/2 teaspoon pepper
  • 6 ounces cheddar shredded
  • 3 ounces mozzarella shredded
  • 3 cups cooked shredded chicken
  • 10.5 ounces Ro*Tel drained
  • 2 cloves garlic minced
  • 1 teaspoon onion powder
  • Chives for garnish

Instructions

To cook the spaghetti squash:

  • To cook in the oven, preheat oven to 400 degrees. Cut the squash in half length-wise and scoop out the seeds with a spoon. Discard the seeds. Drizzle with olive oil and place face down on a baking sheet. Bake for 1 hour or until squash is fork tender.
  • Once squash is cooked, shred the squash into long spaghetti-like strands by using a fork to scrape the squash widthwise. 
  • Place the strands of squash in a large mixing bowl.

To make the cheese sauce:

  • Add the heavy cream, cream cheese, and butter to a medium sauce pan and cook over medium heat until the butter and cream cheese have melted, stirring often.
  • Whisk in the ground mustard and pepper.
  • Remove from the heat and whisk in the cheddar and mozzarella until the mixture is smooth and creamy.

To assemble:

  • Reduce oven heat to 350 degrees. Spray a 9x13 baking dish with non-stick spray. 
  • Add the chicken, Ro*Tel, garlic, and onion powder to the mixing bowl with the spaghetti squash.
  • Pour the cheese sauce over the top and stir gently to coat. 
  • Pour mixture into the prepared baking dish and bake for 20 minutes or until hot and bubbly. 
  • Sprinkle with chives before serving. 

Video

Notes

3 pounds of spaghetti squash will yield around 4 cups of spaghetti squash strands.
We didn't measure servings by volume. We just divided evenly into 6 portions, however each serving will be around 1 cup.
Rather than roasting the spaghetti squash, you can cook it in the Instant Pot.

Nutrition

Serving: 1cup | Calories: 553kcal | Carbohydrates: 12g | Protein: 30g | Fat: 42g | Saturated Fat: 24g | Polyunsaturated Fat: 14g | Trans Fat: 1g | Cholesterol: 164mg | Sodium: 435mg | Fiber: 2g | Sugar: 6g | Net Carbs: 10g